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Article

Noncompetitive antibody neutralization of IL-10 revealed by protein engineering and x-ray crystallography.

Structure (London, England : 1993) - 1 Jul 2002

Josephson Kristopher, Jones Brandi C, Walter Leigh J, DiGiacomo Ruth, Indelicato Stephen R, Walter Mark R

Abstract excerpt

IL-10 is a dimeric cytokine that must engage its high-affinity cell surface receptor, IL-10R1, to induce multiple cellular activities. Here we report the 1.9 A crystal structure of an engineered IL-10 monomer (IL-10M1) in complex with a neutralizing Fab fragment (9D7Fab). 9D7Fab and IL-10R1 bind distinct nonoverlapping surfaces on IL-10M1. Antagonism of the IL-10M1/IL-10R1 interaction is the result of...

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Share to Allosteric Regulation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12121653
DOI: 10.1016/s0969-2126(02)00791-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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