Article

Structures of the interleukin 11 signalling complex reveal dynamics of gp130 extracellular domains and the inhibitory mechanism of a cytokine variant

2022-07-22

Abstract excerpt

<h4>Summary</h4> Interleukin (IL-)11, an IL-6 family cytokine, has pivotal roles in numerous autoimmune diseases, fibrotic complications, and solid cancers. Despite intense therapeutic targeting efforts, structural understanding of IL-11 signalling and mechanistic insights into current inhibitors is lacking. Here we present cryo-EM and crystal structures of the IL-11 signalling complex, including the complex cont...

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Literature Corpus work: 023bd881-fd45-5051-8a40-cdc2b1999677
DOI: 10.1101/2022.07.21.500383

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