Article
A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.
Nature communications - 26 Jan 2018
Broughton Sophie E, Hercus Timothy R, Nero Tracy L, Kan Winnie L, Barry Emma F, Dottore Mara, Cheung Tung Shing Karen S, Morton Craig J, Dhagat Urmi, Hardy Matthew P, Wilson Nicholas J, Downton Matthew T, Schieber Christine, Hughes Timothy P, Lopez Angel F, Parker Michael W
Abstract excerpt
The interleukin-3 (IL-3) receptor is a cell-surface heterodimer that links the haemopoietic, vascular and immune systems and is overexpressed in acute and chronic myeloid leukaemia progenitor cells. It belongs to the type I cytokine receptor family in which the α-subunits consist of two fibronectin III-like domains that bind cytokine, and a third, evolutionarily unrelated and topologically conserved, N-terminal...
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