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Article

Engineering and crystal structure of a monomeric FLT3 ligand variant.

Acta crystallographica. Section F, Structural biology communications - 1 Apr 2021

Pannecoucke Erwin, Raes Laurens, Savvides Savvas N

Abstract excerpt

The overarching paradigm for the activation of class III and V receptor tyrosine kinases (RTKs) prescribes cytokine-mediated dimerization of the receptor ectodomains and homotypic receptor-receptor interactions. However, structural studies have shown that the hematopoietic receptor FLT3, a class III RTK, does not appear to engage in such receptor-receptor contacts, despite its efficient dimerization by dimeric...

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Identifiers

PMID: 33830077
DOI: 10.1107/S2053230X21003289
PMCID: PMC8034431

Genes

FLT3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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