Article
Molecular characterization of latent GDF8 reveals mechanisms of activation.
Proceedings of the National Academy of Sciences of the United States of America - 30 Jan 2018
Walker Ryan G, McCoy Jason C, Czepnik Magdalena, Mills Melanie J, Hagg Adam, Walton Kelly L, Cotton Thomas R, Hyvönen Marko, Lee Richard T, Gregorevic Paul, Harrison Craig A, Thompson Thomas B
Abstract excerpt
Growth/differentiation factor 8 (GDF8), or myostatin, negatively regulates muscle mass. GDF8 is held in a latent state through interactions with its N-terminal prodomain, much like TGF-β. Using a combination of small-angle X-ray scattering and mutagenesis, we characterized the interactions of GDF8 with its prodomain. Our results show that the prodomain:GDF8 complex can exist in a fully latent state and an...
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