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Article

Development of an IL-6 inhibitor based on the functional analysis of murine IL-6Ralpha(1).

Chemistry & biology - 31 Jul 2009

Wiesinger Monique Y, Haan Serge, Wüller Stefan, Kauffmann Maria-Elisabeth, Recker Tobias, Küster Andrea, Heinrich Peter C, Müller-Newen Gerhard

Abstract excerpt

Dysregulated cytokine production contributes to inflammatory and proliferative diseases. Therefore, inhibition of proinflammatory mediators such as TNF, IL-1, and IL-6 is of great clinical relevance. Actual strategies are aimed at preventing receptor activation through sequestration of the ligand. Here we describe the development of an inhibitor of murine IL-6 based on fused receptor fragments. Molecular...

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Identifiers

PMID: 19635415
DOI: 10.1016/j.chembiol.2009.06.010

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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