Article
Genome-wide association study of hippocampal atrophy rate in non-demented elders.
Aging - 23 Nov 2019
Guo Yu, Xu Wei, Li Jie-Qiong, Ou Ya-Nan, Shen Xue-Ning, Huang Yu-Yuan, Dong Qiang, Tan Lan, Yu Jin-Tai
Abstract excerpt
Hippocampal atrophy rate has been correlated with cognitive decline and its genetic modifiers are still unclear. Here we firstly performed a genome-wide association study (GWAS) to identify genetic loci that regulate hippocampal atrophy rate. Six hundred and two non-Hispanic Caucasian elders without dementia were included from the Alzheimer's Disease Neuroimaging Initiative cohort. Three single nucleotide...
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