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Article

Effect of HMGCR genetic variation on neuroimaging biomarkers in healthy, mild cognitive impairment and Alzheimer's disease cohorts.

Oncotarget - 22 Mar 2016

Cao Lei, Wang Hui-Fu, Tan Lin, Sun Fu-Rong, Tan Meng-Shan, Tan Chen-Chen, Jiang Teng, Yu Jin-Tai, Tan Lan

Abstract excerpt

Alzheimer's disease (AD) has become a considerable public health issue. The mechanisms underlying AD onset and progression remain largely unclear. 3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is a strong functional AD candidate gene because it encodes part of the statin-binding domain of the enzyme, which serves as the rate-limiting step in cholesterol synthesis in all mammalian cells. Here, we...

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Source

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Identifiers

PMID: 26950278
DOI: 10.18632/oncotarget.7797
PMCID: PMC4924644

Genes

HMGCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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