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Article

Genome-wide association study identifies SIAH3 locus influencing the rate of ventricular enlargement in non-demented elders.

Aging - 11 Nov 2019

Li Xian, Chu Shu-Guang, Shen Xue-Ning, Hou Xiao-He, Xu Wei, Ou Ya-Nan, Dong Qiang, Tan Lan, Yu Jin-Tai

Abstract excerpt

Ventricular enlargement occurs in several neurodegenerative and psychiatric diseases. A large genome-wide association study (GWAS) has identified seven loci associated with ventricular volume. The rate of ventricular enlargement increased in the progression of disease from normal cognition to dementia. Here, we aimed to use the rate of ventricular enlargement as an endophenotype for the development and...

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Identifiers

PMID: 31711042
DOI: 10.18632/aging.102435
PMCID: PMC6874439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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