Article
Meta-analyses of genome-wide association studies identify novel loci influencing Japanese white matter hyperintensities.
Journal of human genetics - 1 Jul 2026
Asanomi Yuya, Mitsumori Risa, Yamakawa Akiko, Morizono Takashi, Shigemizu Daichi, Niida Shumpei, Sakurai Takashi, Ozaki Kouichi
Abstract excerpt
White matter hyperintensities (WMH) are common findings on brain magnetic resonance imaging (MRI) in older adults and are associated with an increased risk of dementia and stroke. Although large-scale European genome-wide association studies (GWAS) have identified more than 20 loci associated with WMH, the genetic architecture of WMH in Asian populations has not been fully elucidated. Here, we conducted a GWAS...
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