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Article

Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease.

PloS one - 7 Aug 2009

Potkin Steven G, Guffanti Guia, Lakatos Anita, Turner Jessica A, Kruggel Frithjof, Fallon James H, Saykin Andrew J, Orro Alessandro, Lupoli Sara, Salvi Erika, Weiner Michael, Macciardi Fabio

Abstract excerpt

BACKGROUND: With the exception of APOE epsilon4 allele, the common genetic risk factors for sporadic Alzheimer's Disease (AD) are unknown. METHODS AND FINDINGS: We completed a genome-wide association study on 381 participants in the ADNI (Alzheimer's Disease Neuroimaging Initiative) study. Samples were genotyped using the Illumina Human610-Quad BeadChip. 516,645 unique Single Nucleotide Polymorphisms (SNPs) were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19668339
DOI: 10.1371/journal.pone.0006501
PMCID: PMC2719581

Genes

APOE
TOMM40
ARSB
CAND1
EFNA5
MAGI2
PRUNE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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