Article

The major TMEM106B dementia risk allele affects TMEM106B protein levels and myelin lipid homeostasis in the ageing human hippocampus

2023-01-17

Abstract excerpt

<title>Abstract</title> <p>Background The risk for dementia increases exponentially from the seventh decade of life. Identifying and understanding the biochemical changes that sensitize the ageing brain to neurodegeneration will provide new opportunities for dementia prevention and treatment. This study aimed to determine how ageing and major genetic risk factors for dementia affect the hippocampal proteome and...

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Literature Corpus work: 9242d0d1-41b3-5a2d-a2a9-99d3a618afeb
DOI: 10.21203/rs.3.rs-2392941/v1

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