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Article

Mitogen-activated protein kinase regulation of the phosphodiesterase RegA in early Dictyostelium development.

Microbiology (Reading, England) - 1 Feb 2020

Adhikari Nirakar, Kuburich Nick A, Hadwiger Jeffrey A

Abstract excerpt

Mitogen-activated protein kinase (MAPK) regulation of cAMP-specific phosphodiesterase function has been demonstrated in mammalian cells and suspected to occur in other eukaryotes. Epistasis analysis in the soil amoeba Dictyostelium discoideum suggests the atypical MAPK Erk2 downregulates the function of the cAMP-specific phosphodiesterase RegA to regulate progression of the developmental life cycle. A putative...

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Identifiers

PMID: 31730032
DOI: 10.1099/mic.0.000868
PMCID: PMC7273326

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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