Article
Regulation of Dictyostelium early development genes in signal transduction mutants.
Developmental biology - 1 Sept 1995
Wu L, Hansen D, Franke J, Kessin R H, Podgorski G J
Abstract excerpt
The secreted cyclic nucleotide phosphodiesterase (PDE) and its glycoprotein inhibitor (PDI) are among the first genes expressed when Dictyostelium amoebae begin their development. We used a series of mutants with defects in signal transduction to ask whether cAMP receptors 1 and 3, G alpha2, G beta, adenylyl cyclase (ACA), or the protein kinase A catalytic subunit (PKAcat) are required for the initial appearance...
Topics
- Adenylyl Cyclases
- Animals
- Cyclic AMP-Dependent Protein Kinases
- Dictyostelium
- GTP-Binding Proteins
- Gene Expression Regulation, Developmental
- Mutation
- Phosphodiesterase Inhibitors
- Phosphoric Diester Hydrolases
- Signal Transduction