Article
A novel role of differentiation-inducing factor-1 in Dictyostelium development, assessed by the restoration of a developmental defect in a mutant lacking mitogen-activated protein kinase ERK2.
Development, growth & differentiation - 1 Oct 2000
Kuwayama H, Oyama M, Kubohara Y, Maeda M
Abstract excerpt
It has been previously reported that the differentiating wild-type cells of Dictyostelium discoideum secrete a diffusible factor or factors that are able to rescue the developmental defect in the mutant lacking extracellular signal-regulated kinase 2 (ERK2), encoded by the gene erkB. In the present study, it is demonstrated that differentiation-inducing factor-1 (DIF-1) for stalk cells can mimic the role of the...
Topics
- Animals
- Blotting, Northern
- Cyclic AMP
- Dictyostelium
- Hexanones
- Mitogen-Activated Protein Kinase 1
- Morphogenesis
- Mutation