Article
A cAMP-phosphodiesterase controls PKA-dependent differentiation.
Development (Cambridge, England) - 1 Feb 1998
Shaulsky G, Fuller D, Loomis W F
Abstract excerpt
A cAMP-specific phosphodiesterase was found that is stimulated by binding to the regulatory subunit of cAMP-dependent protein kinase, PKA-R, from either Dictyostelium or mammals. The phosphodiesterase is encoded by the regA gene of Dictyostelium, which was recovered in a mutant screen for strains that sporulate in the absence of signals from prestalk cells. The sequence of RegA predicts that it will function as a...
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