A cAMP-phosphodiesterase controls PKA-dependent differentiation.

doi:10.1242/dev.125.4.691

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Article

A cAMP-phosphodiesterase controls PKA-dependent differentiation.

Development (Cambridge, England) - 1 Feb 1998

Shaulsky G, Fuller D, Loomis W F

Abstract excerpt

A cAMP-specific phosphodiesterase was found that is stimulated by binding to the regulatory subunit of cAMP-dependent protein kinase, PKA-R, from either Dictyostelium or mammals. The phosphodiesterase is encoded by the regA gene of Dictyostelium, which was recovered in a mutant screen for strains...

Topics

3',5'-Cyclic-AMP Phosphodiesterases
Animals
Cyclic AMP-Dependent Protein Kinases
Dictyostelium
Genes, Fungal
Genes, Protozoan
Models, Biological
Mutation
Phenotype
Phosphorylation
Signal Transduction
Spores, Fungal

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