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Article

An intersection of the cAMP/PKA and two-component signal transduction systems in Dictyostelium.

The EMBO journal - 15 May 1998

Thomason P A, Traynor D, Cavet G, Chang W T, Harwood A J, Kay R R

Abstract excerpt

Terminal differentiation of both stalk and spore cells in Dictyostelium can be triggered by activation of cAMP-dependent protein kinase (PKA). A screen for mutants where stalk and spore cells mature in isolation produced three genes which may act as negative regulators of PKA: rdeC (encoding the PKA regulatory subunit), regA and rdeA. The biochemical properties of RegA were studied in detail. One domain is a cAMP...

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Identifiers

PMID: 9582277
DOI: 10.1093/emboj/17.10.2838
PMCID: PMC1170624

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An intersection of the cAMP/PKA and two-component signal transduction systems in Dictyostelium.PMID 9582277Read ↗

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Regulated protein degradation controls PKA function and cell-type differentiation in Dictyostelium.Semantic proximity Read ↗

A conserved signalling pathway for amoebozoan encystation that was co-opted for multicellular development.Semantic proximity Read ↗

An adenylyl cyclase that functions during late development of Dictyostelium.Semantic proximity Read ↗

Adenylate cyclase A acting on PKA mediates induction of stalk formation by cyclic diguanylate at the Dictyostelium organizer.Semantic proximity Read ↗

Signal transduction pathways leading to spore differentiation in Dictyostelium discoideum.Semantic proximity Read ↗

Protein kinase A regulates the Ras, Rap1 and TORC2 pathways in response to the chemoattractant cAMP in Dictyostelium.Semantic proximity Read ↗

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cAMP-dependent protein kinase differentially regulates prestalk and prespore differentiation during Dictyostelium development.Semantic proximity Read ↗

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A role for cAMP-dependent protein kinase A in early Dictyostelium development.Semantic proximity Read ↗

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