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Galpha3 and protein kinase A represent cross-talking pathways for gene expression in Dictyostelium discoideum.

Development, growth & differentiation - 1 Oct 2002

Brandon Maureen A, Mahadeo Dana C, Podgorski Gregory J

Abstract excerpt

Heterotrimeric G proteins and protein kinase A (PKA) are regulators of development in Dictyostelium discoideum. It has been reported that disruption of the Dictyostelium Galpha3 gene (galpha3-) blocks development and expression of several early development genes, characteristics that are reminiscent of mutants lacking the catalytic subunit of PKA (pkac-). The hypothesis that Galpha3 and PKA signaling pathways may...

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PMID: 12392578
DOI: 10.1046/j.1440-169x.2002.00658.x

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