Article
A novel Dictyostelium RasGEF required for chemotaxis and development.
BMC cell biology - 7 Dec 2005
Arigoni Maddalena, Bracco Enrico, Lusche Daniel F, Kae Helmut, Weeks Gerald, Bozzaro Salvatore
Abstract excerpt
BACKGROUND: Ras proteins are guanine-nucleotide-binding enzymes that couple cell surface receptors to intracellular signaling pathways controlling cell proliferation and differentiation, both in lower and higher eukaryotes. They act as molecular switches by cycling between active GTP and inactive GDP-bound states, through the action of two classes of regulatory proteins: a) guanine nucleotide exchange factor...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.