Article
Loss of cAMP-specific phosphodiesterase rescues spore development in G protein mutant in dictyostelium.
Cellular signalling - 1 Feb 2014
Schwebs David J, Nguyen Hoai-Nghia, Miller Jamison A, Hadwiger Jeffrey A
Abstract excerpt
Cyclic AMP (cAMP) is an important intracellular signaling molecule for many G protein-mediated signaling pathways but the specificity of cAMP signaling in cells with multiple signaling pathways is not well-understood. In Dictyostelium, at least two different G protein signaling pathways, mediated by the Gα2 and Gα4 subunits, are involved with cAMP accumulation, spore production, and chemotaxis and the stimulation...
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