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Article

Regulated protein degradation controls PKA function and cell-type differentiation in Dictyostelium.

Genes & development - 1 Jun 2001

Mohanty S, Lee S, Yadava N, Dealy M J, Johnson R S, Firtel R A

Abstract excerpt

Cullins function as scaffolds that, along with F-box/WD40-repeat-containing proteins, mediate the ubiquitination of proteins to target them for degradation by the proteasome. We have identified a cullin CulA that is required at several stages during Dictyostelium development. culA null cells are defective in inducing cell-type-specific gene expression and exhibit defects during aggregation, including reduced...

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Identifiers

PMID: 11390363
DOI: 10.1101/gad.871101
PMCID: PMC312710

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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