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Article

Characterization of a cAMP-stimulated cAMP phosphodiesterase in Dictyostelium discoideum.

The Journal of biological chemistry - 18 Apr 2003

Meima Marcel E, Weening Karin E, Schaap Pauline

Abstract excerpt

A cyclic nucleotide phosphodiesterase, PdeE, that harbors two cyclic nucleotide binding motifs and a binuclear Zn(2+)-binding domain was characterized in Dictyostelium. In other eukaryotes, the Dictyostelium domain shows greatest homology to the 73-kDa subunit of the pre-mRNA cleavage and polyadenylation specificity factor. The Dictyostelium PdeE gene is expressed at its highest levels during aggregation, and its...

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PMID: 12574165
DOI: 10.1074/jbc.M209648200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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