Article
Functional and topographic effects on DNA methylation in IDH1/2 mutant cancers.
Scientific reports - 14 Nov 2019
Bledea Ramona, Vasudevaraja Varshini, Patel Seema, Stafford James, Serrano Jonathan, Esposito Gianna, Tredwin Lilian M, Goodman Nina, Kloetgen Andreas, Golfinos John G, Zagzag David, Weigelt Britta, Iafrate A John, Sulman Erik P, Chi Andrew S, Dogan Snjezana, Reis-Filho Jorge S, Chiang Sarah, Placantonakis Dimitris, Tsirigos Aristotelis, Snuderl Matija
Abstract excerpt
IDH1/2 mutations are early drivers present in diverse human cancer types arising in various tissue sites. IDH1/2 mutation is known to induce a global hypermethylator phenotype. However, the effects on DNA methylation across IDH mutant cancers and functionally different genome regions, remain unknown. We analyzed DNA methylation data from IDH1/2 mutant acute myeloid leukemia, oligodendroglioma, astrocytoma, solid...
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