Article
Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles.
Cell reports - 14 Mar 2017
Farshidfar Farshad, Zheng Siyuan, Gingras Marie-Claude, Newton Yulia, Shih Juliann, Robertson A Gordon, Hinoue Toshinori, Hoadley Katherine A, Gibb Ewan A, Roszik Jason, Covington Kyle R, Wu Chia-Chin, Shinbrot Eve, Stransky Nicolas, Hegde Apurva, Yang Ju Dong, Reznik Ed, Sadeghi Sara, Pedamallu Chandra Sekhar, Ojesina Akinyemi I, Hess Julian M, Auman J Todd, Rhie Suhn K, Bowlby Reanne, Borad Mitesh J, Zhu Andrew X, Stuart Josh M, Sander Chris, Akbani Rehan, Cherniack Andrew D, Deshpande Vikram, Mounajjed Taofic, Foo Wai Chin, Torbenson Michael S, Kleiner David E, Laird Peter W, Wheeler David A, McRee Autumn J, Bathe Oliver F, Andersen Jesper B, Bardeesy Nabeel, Roberts Lewis R, Kwong Lawrence N
Abstract excerpt
Cholangiocarcinoma (CCA) is an aggressive malignancy of the bile ducts, with poor prognosis and limited treatment options. Here, we describe the integrated analysis of somatic mutations, RNA expression, copy number, and DNA methylation by The Cancer Genome Atlas of a set of predominantly intrahepatic CCA cases and propose a molecular classification scheme. We identified an IDH mutant-enriched subtype with...
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