IDH2 R172 Mutations Across Poorly Differentiated Sinonasal Tract Malignancies: Forty Molecularly Homogenous and Histologically Variable Cases With Favorable Outcome.

doi:10.1097/PAS.0000000000001697

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Article

IDH2 R172 Mutations Across Poorly Differentiated Sinonasal Tract Malignancies: Forty Molecularly Homogenous and Histologically Variable Cases With Favorable Outcome.

The American journal of surgical pathology - 1 Sept 2021

Glöss Stefanie, Jurmeister Philipp, Thieme Anne, Schmid Simone, Cai Wei Y, Serrette Rene N, Perner Sven, Ribbat-Idel Julika, Pagenstecher Axel, Bläker Hendrik, Keber Ursula, Stadelmann Christine, Zechel Sabrina, Johann Pascal D, Hasselblatt Martin, Paulus Werner, Thomas Christian, Dohmen Hildegard, Baumhoer Daniel, Frank Stephan, Agaimy Abbas, Schüller Ulrich, Vasudevaraja Varshini, Snuderl Matija, Liu Cheng Z, Pfister David G, Jungbluth Achim A, Ghossein Ronald A, Xu Bin, Capper David, Dogan Snjezana

Abstract excerpt

IDH2 R172 mutations occur in sinonasal undifferentiated carcinoma (SNUC), large-cell neuroendocrine carcinoma (LCNEC), sinonasal adenocarcinomas, and olfactory neuroblastoma (ONB). We performed a clinical, pathologic, and genetic/epigenetic analysis of a large IDH2-mutated sinonasal tumor cohort to explore their distinct features. A total 165 sinonasal/skull base tumors included 40 IDH2 mutants studied by light...

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PMID: 34265800
DOI: 10.1097/PAS.0000000000001697
PMCID: PMC8373679

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