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Article

Epigenetic landscape reorganisation and reactivation of embryonic development genes are associated with malignancy in IDH-mutant astrocytoma.

Acta neuropathologica - 9 Oct 2024

Ghisai Santoesha A, van Hijfte Levi, Vallentgoed Wies R, Tesileanu C Mircea S, de Heer Iris, Kros Johan M, Sanson Marc, Gorlia Thierry, Wick Wolfgang, Vogelbaum Michael A, Brandes Alba A, Franceschi Enrico, Clement Paul M, Nowak Anna K, Golfinopoulos Vassilis, van den Bent Martin J, French Pim J, Hoogstrate Youri

Abstract excerpt

Accurate grading of IDH-mutant gliomas defines patient prognosis and guides the treatment path. Histological grading is challenging, and aside from CDKN2A/B homozygous deletions in IDH-mutant astrocytomas, there are no other objective molecular markers used for grading. RNA-sequencing was conducted on primary IDH-mutant astrocytomas (n = 138) included in the prospective CATNON trial, which was performed to assess...

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Identifiers

PMID: 39382765
DOI: 10.1007/s00401-024-02811-0
PMCID: PMC11464554

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