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Article

Longitudinal DNA methylation analysis of adult-type IDH-mutant gliomas.

Acta neuropathologica communications - 4 Feb 2023

Ferreyra Vega Sandra, Olsson Bontell Thomas, Kling Teresia, Jakola Asgeir Store, Carén Helena

Abstract excerpt

Diffuse gliomas are the most prevalent malignant primary brain tumors in adults and remain incurable despite standard therapy. Tumor recurrence is currently inevitable, which contributes to a persistent high morbidity and mortality in these patients. In this study, we examined the genome-wide DNA methylation profiles of primary and recurrent adult-type IDH-mutant gliomas to elucidate DNA methylation changes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36739454
DOI: 10.1186/s40478-023-01520-1
PMCID: PMC9899392

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