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Article

POT1-TPP1 differentially regulates telomerase via POT1 His266 and as a function of single-stranded telomere DNA length.

Proceedings of the National Academy of Sciences of the United States of America - 19 Nov 2019

Xu Mengyuan, Kiselar Janna, Whited Tawna L, Hernandez-Sanchez Wilnelly, Taylor Derek J

Abstract excerpt

Telomeres cap the ends of linear chromosomes and terminate in a single-stranded DNA (ssDNA) overhang recognized by POT1-TPP1 heterodimers to help regulate telomere length homeostasis. Here hydroxyl radical footprinting coupled with mass spectrometry was employed to probe protein-protein interactions and conformational changes involved in the assembly of telomere ssDNA substrates of differing lengths bound by...

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Identifiers

PMID: 31685617
DOI: 10.1073/pnas.1905381116
PMCID: PMC6876245

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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