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Article

DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA.

Nature - 13 Nov 2003

Lei Ming, Podell Elaine R, Baumann Peter, Cech Thomas R

Abstract excerpt

Telomeres, specialized protein-DNA complexes that cap the ends of linear chromosomes, are essential for protecting chromosomes from degradation and end-to-end fusions. The Pot1 (protection of telomeres 1) protein is a widely distributed eukaryotic end-capping protein, having been identified in fission yeast, microsporidia, plants and animals. Schizosaccharomyces pombe Pot1p is essential for telomere maintenance,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14614509
DOI: 10.1038/nature02092

Genes

POT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA.PMID 14614509Read ↗

Tying up the Ends: Plasticity in the Recognition of Single-Stranded DNA at TelomeresSemantic proximity Read ↗

Protection of telomeres by a conserved Stn1–Ten1 complexSemantic proximity Read ↗

How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNASemantic proximity Read ↗

Dynamic peptides of human TPP1 fulfill diverse functions in telomere maintenance.Semantic proximity Read ↗

Human POT1 protects the telomeric ds-ss DNA junction by capping the 5' end of the chromosome.Semantic proximity Read ↗

Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length.Semantic proximity Read ↗

Pot1, the putative telomere end-binding protein in fission yeast and humans.Semantic proximity Read ↗

Structural and functional analysis of the human POT1-TPP1 telomeric complex.Semantic proximity Read ↗

PTOP interacts with POT1 and regulates its localization to telomeres.Semantic proximity Read ↗

OB Fold-containing Protein 1 (OBFC1), a Human Homolog of Yeast Stn1, Associates with TPP1 and Is Implicated in Telomere Length RegulationSemantic proximity Read ↗

A Data-Analysis Pipeline for High-Throughput Systematic Evolution of Ligands by Exponential Enrichment (HT-SELEX) in the Characterization of Telomeric ProteinsSemantic proximity Read ↗

Distinct functions of POT1 at telomeres.Semantic proximity Read ↗

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