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Article

Dynamic peptides of human TPP1 fulfill diverse functions in telomere maintenance.

Nucleic acids research - 1 Dec 2016

Rajavel Malligarjunan, Orban Tivadar, Xu Mengyuan, Hernandez-Sanchez Wilnelly, de la Fuente Maria, Palczewski Krzysztof, Taylor Derek J

Abstract excerpt

Telomeres are specialized nucleoprotein complexes that comprise the ends of linear chromosomes. Human telomeres end in a short, single-stranded DNA (ssDNA) overhang that is recognized and bound by two telomere proteins, POT1 and TPP1. Whereas POT1 binds directly to telomere ssDNA, its interaction with TPP1 is essential for localization of POT1 to the telomere. TPP1 also provides enhanced binding and sequence...

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Source

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Identifiers

PMID: 27655633
DOI: 10.1093/nar/gkw846
PMCID: PMC5137443

Genes

TPP1
POT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dynamic peptides of human TPP1 fulfill diverse functions in telomere maintenance.PMID 27655633Read ↗

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