Article
Distinct functions of POT1 at telomeres.
Molecular and cellular biology - 1 Sept 2008
Barrientos Katharine S, Kendellen Megan F, Freibaum Brian D, Armbruster Blaine N, Etheridge Katherine T, Counter Christopher M
Abstract excerpt
The mammalian protein POT1 binds to telomeric single-stranded DNA (ssDNA), protecting chromosome ends from being detected as sites of DNA damage. POT1 is composed of an N-terminal ssDNA-binding domain and a C-terminal protein interaction domain. With regard to the latter, POT1 heterodimerizes with the protein TPP1 to foster binding to telomeric ssDNA in vitro and binds the telomeric double-stranded-DNA-binding...
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