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Article

Active and Passive Destabilization of G-Quadruplex DNA by the Telomere POT1-TPP1 Complex.

Journal of molecular biology - 2 Apr 2021

Xu Mengyuan, Axhemi Armend, Malgowska Magdalena, Chen Yinghua, Leonard Daniel, Srinivasan Sukanya, Jankowsky Eckhard, Taylor Derek J

Abstract excerpt

Chromosome ends are protected by guanosine-rich telomere DNA that forms stable G-quadruplex (G4) structures. The heterodimeric POT1-TPP1 complex interacts specifically with telomere DNA to shield it from illicit DNA damage repair and to resolve secondary structure that impedes telomere extension. The mechanism by which POT1-TPP1 accomplishes these tasks is poorly understood. Here, we establish the kinetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33549587
DOI: 10.1016/j.jmb.2021.166846
PMCID: PMC8020995

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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