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Article

Functional diversity of human protection of telomeres 1 isoforms in telomere protection and cellular senescence.

Cancer research - 15 Dec 2007

Yang Qin, Zhang Ran, Horikawa Izumi, Fujita Kaori, Afshar Yalda, Kokko Antti, Laiho Päivi, Aaltonen Lauri A, Harris Curtis C

Abstract excerpt

Protection of telomeres 1 (POT1) proteins in various organisms bind telomeres and regulate their structure and function. In contrast to mice carrying two distinct POT1 genes encoding two POT1 proteins (POT1a and POT1b), humans have the single POT1 gene. In addition to full-length POT1 protein (variant v1), the human POT1 gene encodes four other variants due to alternative RNA splicing (variants v2, v3, v4, and...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18089797
DOI: 10.1158/0008-5472.CAN-07-1390

Genes

POT1
TPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional diversity of human protection of telomeres 1 isoforms in telomere protection and cellular senescence.PMID 18089797Read ↗

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Human Pot1 (Protection of Telomeres) Protein: Cytolocalization, Gene Structure, and Alternative SplicingSemantic proximity Read ↗

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