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Article

Engineered Reader Proteins for Enhanced Detection of Methylated Lysine on Histones.

ACS chemical biology - 17 Jan 2020

Albanese Katherine I, Krone Mackenzie W, Petell Christopher J, Parker Madison M, Strahl Brian D, Brustad Eric M, Waters Marcey L

Abstract excerpt

Histone post-translational modifications (PTMs) are crucial for many cellular processes including mitosis, transcription, and DNA repair. The cellular readout of histone PTMs is dependent on both the chemical modification and histone site, and the array of histone PTMs on chromatin is dynamic throughout the eukaryotic life cycle. Accordingly, methods that report on the presence of PTMs are essential tools for...

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Share to Chromatin
Share to Chromobox Protein Homolog 5

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histones

Share to Lysine

Share to Methylation

Share to Nucleosomes

Share to Protein Processing, Post-Translational

Share to Substrate Specificity

Source

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Identifiers

PMID: 31634430
DOI: 10.1021/acschembio.9b00651
PMCID: PMC7365037

Genes

CBX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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