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Chemical Epigenetics: The Impact of Chemical and Chemical Biology Techniques on Bromodomain Target Validation

11 Jan 2019

Abstract excerpt

Epigenetics is currently the focus of intense research interest across a broad range of disciplines due to its importance in a multitude of biological processes and disease states. Epigenetic functions result partly from modification of the nucleobases in DNA and RNA, and/or post-translational modifications of histone proteins. These modifications are dynamic, with cellular machinery identified to modulate and...

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PMID: 30633431
DOI: 10.1002/anie.201812164

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