Article
Characterization of the histone methyltransferase PRDM9 using biochemical, biophysical and chemical biology techniques.
The Biochemical journal - 15 Jul 2014
Koh-Stenta Xiaoying, Joy Joma, Poulsen Anders, Li Rong, Tan Yvonne, Shim Yoonjung, Min Jung-Hyun, Wu Liling, Ngo Anna, Peng Jianhe, Seetoh Wei Guang, Cao Jing, Wee John Liang Kuan, Kwek Perlyn Zekui, Hung Alvin, Lakshmanan Umayal, Flotow Horst, Guccione Ernesto, Hill Jeffrey
Abstract excerpt
PRDM proteins have emerged as important regulators of disease and developmental processes. To gain insight into the mechanistic actions of the PRDM family, we have performed comprehensive characterization of a prototype member protein, the histone methyltransferase PRDM9, using biochemical, biophysical and chemical biology techniques. In the present paper we report the first known molecular characterization of a...
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