KDM2A integrates DNA and histone modification signals through a CXXC/PHD module and direct interaction with HP1.

doi:10.1093/nar/gkw979

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Article

KDM2A integrates DNA and histone modification signals through a CXXC/PHD module and direct interaction with HP1.

Nucleic acids research - 17 Feb 2017

Borgel Julie, Tyl Marek, Schiller Karin, Pusztai Zsofia, Dooley Christopher M, Deng Wen, Wooding Carol, White Richard J, Warnecke Tobias, Leonhardt Heinrich, Busch-Nentwich Elisabeth M, Bartke Till

Abstract excerpt

Functional genomic elements are marked by characteristic DNA and histone modification signatures. How combinatorial chromatin modification states are recognized by epigenetic reader proteins and how this is linked to their biological function is largely unknown. Here we provide a detailed molecular analysis of chromatin recognition by the lysine demethylase KDM2A. Using biochemical approaches we identify a...

Topics

Animals
Animals, Genetically Modified
Cell Line
Chromobox Protein Homolog 5
Chromosomal Proteins, Non-Histone
CpG Islands
Cricetinae
DNA Methylation
F-Box Proteins
HEK293 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HeLa Cells

Histones

Humans

Jumonji Domain-Containing Histone Demethylases

Models, Genetic

Mutation

Neoplasms

Nucleosomes

Source

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Identifiers

PMID: 28180290
DOI: 10.1093/nar/gkw979
PMCID: PMC5388433

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