Article
A circular engineered sortase for interrogating histone H3 in chromatin
2024-09-10
Abstract excerpt
Reversible modification of the histone H3 N-terminal tail is critical in regulating chromatin structure, gene expression, and cell states, while its dysregulation contributes to disease pathogenesis. Understanding the crosstalk between H3 tail modifications in nucleosomes constitutes a central challenge in epigenetics. Here we describe an engineered sortase transpeptidase, cW11, that displays highly favorable prop...
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Identifiers and source
- Literature Corpus work
- 3a91f98d-49ea-5fb9-a575-7bfda49b01d5
- DOI
- 10.1101/2024.09.10.612318