Investigation of the β-sheet interactions between dHP1 chromodomain and histone 3.

doi:10.1021/acs.biochem.5b00024

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Article

Investigation of the β-sheet interactions between dHP1 chromodomain and histone 3.

Biochemistry - 14 Apr 2015

Eisert Robyn J, Kennedy Sarah A, Waters Marcey L

Abstract excerpt

Methylated lysine 9 on the histone 3 (H3) tail recruits heterochromatin protein 1 from Drosophila (dHP1) via its chromodomain and results in gene silencing. The dHP1 chromodomain binds H3 K9Me3 with an aromatic cage surrounding the trimethyllysine. The sequence selectivity of binding comes from insertion of the histone tail between two β-strands of the chromodomain to form a three-stranded β-sheet. Herein, we...

Topics

Chromosomal Proteins, Non-Histone
Circular Dichroism
Drosophila Proteins
Fluorescence Polarization
Histones
Mutation
Protein Binding
Protein Structure, Secondary
Protein Structure, Tertiary
Thermodynamics

Source

Open in PubMed

Identifiers

PMID: 25790265
DOI: 10.1021/acs.biochem.5b00024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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