Article
In situ chromatin interactomics using a chemical bait and trap approach.
Nature chemistry - 1 Jun 2020
Burton Antony J, Haugbro Michael, Gates Leah A, Bagert John D, Allis C David, Muir Tom W
Abstract excerpt
Elucidating the physiological binding partners of histone post-translational modifications (hPTMs) is key to understanding fundamental epigenetic regulatory pathways. Determining such interactomes will enable the study of how perturbations of these interactions affect disease. Here we use a synthetic biology approach to set a series of hPTM-controlled photo-affinity traps in native chromatin. Using quantitative...
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