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Article

Germ-line genetic variation in the immunoglobulin heavy chain creates stroke susceptibility in the spontaneously hypertensive rat.

Physiological genomics - 1 Nov 2019

Dhande Isha S, Kneedler Sterling C, Joshi Aniket S, Zhu Yaming, Hicks M John, Wenderfer Scott E, Braun Michael C, Doris Peter A

Abstract excerpt

The risk of cerebrovascular disease in stroke-prone spontaneously hypertensive rats (SHR-A3/SHRSP) arises from naturally occurring genetic variation. In the present study we show the involvement of SHR genetic variation that affects antibody formation and function in the pathogenesis of stroke. We have tested the involvement in susceptibility to stroke of genetic variation in IgH, the gene encoding the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31608789
DOI: 10.1152/physiolgenomics.00054.2019
PMCID: PMC6879812

Genes

FABP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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