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Article

Polygenic genetic variation affecting antibody formation underlies hypertensive renal injury in the stroke-prone spontaneously hypertensive rat.

American journal of physiology. Renal physiology - 1 Sept 2023

Dhande Isha S, Zhu Yaming, Joshi Aniket S, Hicks M John, Braun Michael C, Doris Peter A

Abstract excerpt

During development of the spontaneously hypertensive rat (SHR), several distinct but closely related lines were generated. Most lines are resistant to hypertensive renal disease. However, the SHR-A3 line (stroke-prone SHR) experiences end-organ injury (EOI) and provides a model of injury susceptibility that can be used to uncover genetic causation. In the present study, we generated a congenic line in which three...

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Share to Antibody Formation
Share to Blood Pressure

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypertension

Share to Hypertension, Renal

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Share to Rats, Inbred SHR

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Source

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Identifiers

PMID: 37439198
DOI: 10.1152/ajprenal.00058.2023
PMCID: PMC10511163

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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