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Article

Chromosomal mapping of quantitative trait loci contributing to stroke in a rat model of complex human disease.

Nature genetics - 1 Aug 1996

Rubattu S, Volpe M, Kreutz R, Ganten U, Ganten D, Lindpaintner K

Abstract excerpt

Stroke is a complex disorder with a poorly understood multifactorial and polygenic aetiology. We used the stroke-prone spontaneously hypertensive rat (SHRSP) as a model organism, mated it with the stroke-resistant spontaneously hypertensive rat (SHR) and performed a genome-wide screen in the resultant F2 cohort where latency until stroke, but not hypertension (a major confounder) segregated. We identified three...

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Identifiers

PMID: 8696337
DOI: 10.1038/ng0896-429

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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