Article
Immunoglobulin locus associates with serum IgG levels and albuminuria.
Journal of the American Society of Nephrology : JASN - 1 May 2011
Herring Stacy M, Gokul Nisha, Monita Monique, Bell Rebecca, Boerwinkle Eric, Wenderfer Scott E, Braun Michael C, Doris Peter A
Abstract excerpt
The interaction between IgG and Fc-γ receptors in glomeruli contributes to the development of several types of proteinuric glomerular disease, but the involvement of immunological mechanisms in hypertensive renal injury is incompletely understood. Here, we investigated serum IgG levels in SHR-A3 rats, which develop hypertensive injury, and compared them with the injury-resistant SHR-B2 line. At 18 weeks old,...
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