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Article

Natural genetic variation in Stim1 creates stroke in the spontaneously hypertensive rat.

Genes and immunity - 1 May 2020

Dhande Isha S, Kneedler Sterling C, Zhu Yaming, Joshi Aniket S, Hicks M John, Wenderfer Scott E, Braun Michael C, Doris Peter A

Abstract excerpt

Similar to humans, the risk of cerebrovascular disease in stroke-prone spontaneously hypertensive rats (SHR-A3/SHRSP) arises from naturally occurring genetic variation. In the present study, we show the involvement of genetic variation affecting the store-operated calcium signaling gene, Stim1, in the pathogenesis of stroke in SHR. Stim1 is a key lymphocyte activation signaling molecule and contains functional...

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Identifiers

PMID: 32300198
DOI: 10.1038/s41435-020-0097-5
PMCID: PMC7274944

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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