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Evidence for a Causal Role of the SH2B3 -β 2 M Axis in Blood Pressure Regulation

9 Jan 2019

Abstract excerpt

Genetic variants at SH2B3 are associated with blood pressure and circulating β 2 M (β-2 microglobulin), a well-characterized kidney filtration biomarker. We hypothesize that circulating β 2 M is an independent risk predictor of hypertension and may causally contribute to its development. The study sample consisted of 7 065 Framingham Heart Study participants with measurements of plasma β 2 M. Generalized...

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Genetic Associations and Epidemiology
Hormonal Regulation and Hypertension
Renin-Angiotensin System Studies

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30624993
DOI: 10.1161/hypertensionaha.118.12094

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