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Article

Vascular effects of the human extracellular superoxide dismutase R213G variant.

Circulation - 16 Aug 2005

Chu Yi, Alwahdani Abdullah, Iida Shinichiro, Lund Donald D, Faraci Frank M, Heistad Donald D

Abstract excerpt

BACKGROUND: Extracellular superoxide dismutase (ECSOD) is a major extracellular antioxidant enzyme. We have demonstrated that vascular effects of ECSOD require an intact heparin-binding domain. A common genetic variant with a substitution in the heparin-binding domain (ECSOD(R213G)) was reported recently to be associated with ischemic heart disease. The goal of this study was to examine vascular effects of...

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Identifiers

PMID: 16087794
DOI: 10.1161/CIRCULATIONAHA.104.531251

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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