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Article

Diversity in the preimmune immunoglobulin repertoire of SHR lines susceptible and resistant to end-organ injury.

Genes and immunity - 1 Dec 2014

Gonzalez-Garay M L, Cranford S M, Braun M C, Doris P A

Abstract excerpt

We used next-generation sequencing to identify immunoglobulin heavy chain (IGH) genetic variation in two closely related hypertensive rat lines that differ in susceptibility to end-organ disease (SHR-A3 and SHR-B2). The two SHR lines differ extensively at the IGH locus from the rat reference genome sequence and from each other, creating 306 sequence unique IGH genes. Compared with IGH genes mapped in the rat...

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Share to Genes, Immunoglobulin Heavy Chain
Share to High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypertension

Share to Rats, Inbred SHR

Share to Renal Insufficiency

Share to Sequence Homology, Amino Acid

Share to Sequence Homology, Nucleic Acid

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Source

Open in PubMed Open full text

Identifiers

PMID: 25056448
DOI: 10.1038/gene.2014.40
PMCID: PMC4257902

Genes

IGH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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