Article
Hypertensive renal injury is associated with gene variation affecting immune signaling.
Circulation. Cardiovascular genetics - 1 Dec 2014
Braun Michael C, Herring Stacy M, Gokul Nisha, Monita Monique, Bell Rebecca, Zhu Yaming, Gonzalez-Garay Manuel L, Wenderfer Scott E, Doris Peter A
Abstract excerpt
BACKGROUND: The spontaneously hypertensive rat (SHR) strain exists in lines that contrast strongly in susceptibility to renal injury in hypertension. These inbred lines share common ancestry, and only 13% of their genomes arise from different ancestors. METHODS AND RESULTS: We used next gen sequencing to detect natural allelic variation in 5 genes of the immunoreceptor signaling pathway (IgH, Dok3, Src, Syk, and...
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