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White matter integrity and its association with amyloid-PET and serum NfL in healthy<i>APOE4</i>homozygotes, heterozygotes and non-carries

2023-10-28

Abstract excerpt

Except for aging, APOE ε4 allele ( APOE4 ) is the most important risk factor for sporadic Alzheimer’s disease. APOE4 carriers may have reduced capacity to recycle lipids, resulting in reduced white matter integrity. Here, we evaluated if white matter impairment measured by diffusion tensor imaging (DTI) differs between healthy individuals with different number of APOE4 alleles and if white matter impairment associ...

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Literature Corpus work
139962c7-4568-577d-ab9b-d68ff3478424
DOI
10.1101/2023.10.27.23297664
Open publication

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White matter integrity and its association with amyloid-PET and serum NfL in healthy<i>APOE4</i>homozygotes, heterozygotes and non-carriesDOI 10.1101/2023.10.27.23297664
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